This report shows that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells.
This review discusses the factors that make it difficult to use individual genome sequences in a predictive manner to determine disease susceptibility, including epigenetics.
This work by Schuster-Boeckler and Lehner suggests that the arrangement of the genome into heterochromatin- and euchromatin-like domains is a dominant influence on regional mutation-rate variation in human somatic cells.
The authors show here that ZRF1 regulates the INK4-ARF locus during cellular proliferation and senescence, and alterations in ZRF1 may contribute to tumorigenesis.
