publication

Here, the Berger group highlights recent major achievements in multiprotein complex structure research that were catalyzed by this versatile recombinant complex expression tool.

Here, Park and Lehner propose that the tight regulation of epistatic interaction network hubs is critical for maintaining a robust phenotype.

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Brian Hendrich and coworkers review the evidence for the presence of repressors at actively transcribed regions and assess what roles they might be playing. They propose that the modulation of expression levels by chromatin-modifying, co-repressor complexes provides transcriptional fine-tuning that drives development.

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Until now, the inability to produce enough high-quality recombinant complex has hindered scientists from obtaining the structural information necessary to fully understand the molecular function of the general transcription factor TFIID. Several groups led by the Berger team have now elucidated a high-resolution structure (11.6Å) for the core TFIID complex, a 650 kDa complex containing ten protein subunits. Their findings, published in Nature, now reveal the architecture of the core TFIID and answer several long-standing questions about TFIID.

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