In a highly collaborative effort from three 4DCellFate labs, the authors show that a H2Aub-mediated feedback loop is required for establishing Polycomb repression.
Together with collaborators, the Di Croce group uncovered details about the molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs).
This publication from the labs of Aznar-Benitah, Lehner, and Serrano reveals that skin cells activate genes depending on the their internal circadian rhythms.
DPY30 is a key regulator of the proliferation potential of human primary cells that controls proliferation by regulating ID proteins expression, which in turn lead to senescence bypass, as shown in work from the Di Croce team.
