publication | 4DCellFate

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression — C. Müller, Vermeulen, and J. Müller labs (2014)

In a highly collaborative effort from three 4DCellFate labs, the authors show that a H2Aub-mediated feedback loop is required for establishing Polycomb repression.

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4DCellFate collaborative publication

MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG binding domain — Vermeulen and collaborator labs (2014)

This work revealed a shared function between MBD5 and MBD6 through their interaction with PR-DUB and MBD6-specific recruitment to sites of DNA damage.

Synonymous mutations frequently act as driver mutations in human cancers — Lehner and collaborator labs (2014)

Reassessing data from large-scale sequencing of cancer genomes allowed the authors to analyze unbiasedly the contribution of mutations to cancer.

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Zrf1 is required to establish and maintain neural progenitor identity —Di Croce lab (2014)

Together with collaborators, the Di Croce group uncovered details about the molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs).

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The effects of genetic variation on gene expression dynamics during development —Lehner lab (2014)

The Lehner lab describes an elegant approach of how to analyze how local and distant genetic variations influence gene expression dynamics.

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Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements—J. Müller and C. Müller labs (2013)

The groups of Christoph Müller and Jürg Müller have elucidated the molecular mechanisms for specific DNA binding of PcG complexes.

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4DCellFate collaborative publication

Human epidermal stem cell function is regulated by circadian oscillations–Lehner and collaborator labs (2013)

This publication from the labs of Aznar-Benitah, Lehner, and Serrano reveals that skin cells activate genes depending on the their internal circadian rhythms.

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Transcriptional regulation by Polycomb group proteins — Di Croce and Helin (2013)

An excellent overview of our current knowledge about Polycomb proteins.

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4DCellFate collaborative publication

DPY30 regulates pathways in cellular senescence through ID protein expression — Di Croce and collaborator labs (2013)

DPY30 is a key regulator of the proliferation potential of human primary cells that controls proliferation by regulating ID proteins expression, which in turn lead to senescence bypass, as shown in work from the Di Croce team.

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CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now — Heinrich lab (2013)

Review by O'Shaughnessy and Hendrich that describes that CHD4 is a defining member of the NuRD complex, but evidence is accumulating that CHD4 also plays important NuRD-independent roles in the DNA-damage response and cell cycle progression, as well as in transcriptional regulation.

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