In this article Kloet et al. show that the stoichiometry and genome-wide binding of PRC1 and PRC2 were highly dynamic during neural differentiation. The analyses uncovered dynamic PcG subcomplexes and their widespread colocalization with active chromatin marks during differentiation.
In this paper Pasisni and Di Croce analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.
In this paper Sebe-Pedros et al. suggest that the appearance of developmental promoters and distal enhancer elements, rather than of gene innovations, may have been the critical events underlying the origin of multicellular organisms.
In this paper Jain and Di Croce discuss, which mutations and deletions of the PRC2 complex have been detected in different cancers, with a specific focus on the overexpression of EZH2 in prostate cancer.
This study of Matthews et al. demonstrates the importance of HDAC3 for the proliferation of leukemia and lymphoma cells, suggesting that HDAC3-selective inhibitors could prove useful for the treatment of hematological malignancies.