publication

In this publication Pascual et al. show that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis.

In this article Beringer et al. show, that Elongin BC is recruited to chromatin by the PRC2-associated factor EPOP (Elongin BC and Polycomb Repressive Complex 2 Associated Protein). Both EPOP and Elongin BC are required to maintain low levels of expression at PRC2 genomic targets. The results indicate that keeping the balance between activating and repressive cues is a more general feature of chromatin in pluripotent stem cells than previously appreciated.

In this paper Spruijt et al. show that ZMYND8 bridges NuRD to a number of putative DNA-binding zinc finger proteins. The MYND domain of ZMYND8 directly interacts with PPPLΦ motifs in the NuRD subunit GATAD2A.

Comet et al. propose in this article that the opposing roles of PRC2 in cancer are a consequence of the molecular function of the complex in maintaining, rather than specifying, the transcriptional repression state of its several thousand target genes.