4DCellFate

Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease

4DCellFate collaborative publication

By determining the structure of MTA1-RbAp48 structure, the authors were able to reveal that the MTA subunits act as scaffolds for NuRD complex assembly.

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In a highly collaborative effort from three 4DCellFate labs, the authors show that a H2Aub-mediated feedback loop is required for establishing Polycomb repression.

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The groups of Christoph Müller and Jürg Müller have elucidated the molecular mechanisms for specific DNA binding of PcG complexes.

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Until now, the inability to produce enough high-quality recombinant complex has hindered scientists from obtaining the structural information necessary to fully understand the molecular function of the general transcription factor TFIID. Several groups led by the Berger team have now elucidated a high-resolution structure (11.6Å) for the core TFIID complex, a 650 kDa complex containing ten protein subunits. Their findings, published in Nature, now reveal the architecture of the core TFIID and answer several long-standing questions about TFIID.

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This manuscript shows how the structural plasticity of the core histones H3-H4 can play a mechanistic role in epigenetic inheritance.

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