Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease


Structural & Functional Proteomics: Delving into Molecular Details 2013

The workshop “Structural and Functional Proteomics: Delving into Molecular Details” was held in Utrecht, 14-15 January, 2013.

This workshop was organized by Michiel Vermeulen and Frank Sobott, and was co-sponsored by 4DCellFate, the Cancer Genomics Centre (CGC), and Waters. The workshop took place in La Vie Utrecht (Lange Viestraat 351). It was open to the public, and no registration is required. Please find the program (with directions to reach the venue) attached below.

A mini-symposium with world-class researchers will highlight cutting-edge topics from the field of proteomics, such as the role of post-translational modifications on interaction proteomics. These talks are open to the public, and participants will have the chance tonetwork over coffee during the day or a drink afterward the talks.   

A practical tutorial will be held specifically for 4DCellFate members on Tuesday afternoon. This interactive tutorial will deal with topics of interest, such as how to carry out the analysis of MS results. 4DCellFate members will also attend a dinner with the speakers on Monday evening, to promote networking within the consortium and with the speakers. 


January 14

13:30 – 14:00        Registration

14:00 – 14:05        Frank Sobott: introduction

14:05 – 14:35        Albert Heck

Native mass spectrometry: a bridge between interactomics and structural biology

14:35 – 15:05        Kasper Rand

Analysis of protein conformation and interaccions by H/D exchange mass spectrometry (HDX-MS)

15:05 – 15:35        Frank Sobott

Ion mobility-MS for native proteins and complexes

15:35 – 16:05        Coffee break

16:05 – 16:35        Juri Rappsilber

Determining complex protein networks with residue-level resolution - science fiction or science reality?

16:35 – 17:05        Alex Leitner

An integrated workflow for chemical cross-linking/mass spectrometry: technology and applications

17:05 – 17:35        Henning Urlaub

Mass spectrometric investigations of protein-RNA interactions

17:35 – 19:00        Discussion/Beer session (open)

19:30 – 22:00        Dinner with speakers (4DCellFate only)

January 15

9:00 – 9:05            Michiel Vermeulen: introduction

9:05 – 9:35            Anne-Claude Gavin

Systematic screens for protein–lipid interactions in Saccharomyces cerevisiae

9:35 – 10:05           Tiziana Bonaldi

The regulatory potential of protein methylation in gene expression investigated by MS-based proteomics

10:05 – 10:35           Coffee break

10:35 – 11:05           Jesper Olsen

Global proteomic analysis of PTMs in tissue samples

11:05 – 11:35           Matthias Selbach

Proteome dynamics

11:35 – 12:05           Michiel Vermeulen

Quantitative proteomics reveals dynamic readers for 5-(hydroxy)methylcytosine during development

12:15 – 14:00           Lunch buffet

14:00 – 17:00           Workshop (4DCellFate only)


Jan 14 to Jan 15