Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease

Transcriptional regulation by Polycomb group proteins — Di Croce and Helin (2013)

Luciano Di Croce and Kristian Helin

This collaborative review from two 4DCellFate scientists provides a timely overview to the highly-intricate pathways involved in Polycomb transcriptional regulation.


Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease. Mechanistically, they function within multiprotein complexes, called Polycomb repressive complexes (PRCs), which modify histones (and other proteins) and silence target genes. The dynamics of PRC1 and PRC2 components has been the focus of recent research. Here we discuss our current knowledge of the PRC complexes, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity. 

Nat Struct & Mol Biol (2013) 20, 1147-115.  doi:10.1038/nsmb.2669