4DCellFate

Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease

This manuscript shows how the structural plasticity of the core histones H3-H4 can play a mechanistic role in epigenetic inheritance.

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Here, Vavouri and Lehner report that genes with CpG island promoters have a characteristic transcription-associated chromatin organization.

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This report shows that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells.

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This review discusses the factors that make it difficult to use individual genome sequences in a predictive manner to determine disease susceptibility, including epigenetics.

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This work by Schuster-Boeckler and Lehner suggests that the arrangement of the genome into heterochromatin- and euchromatin-like domains is a dominant influence on regional mutation-rate variation in human somatic cells.

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The authors show here that ZRF1 regulates the INK4-ARF locus during cellular proliferation and senescence, and alterations in ZRF1 may contribute to tumorigenesis.

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