4DCellFate

Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease

In a highly collaborative effort from three 4DCellFate labs, the authors show that a H2Aub-mediated feedback loop is required for establishing Polycomb repression.

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This work revealed a shared function between MBD5 and MBD6 through their interaction with PR-DUB and MBD6-specific recruitment to sites of DNA damage.

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Reassessing data from large-scale sequencing of cancer genomes allowed the authors to analyze unbiasedly the contribution of mutations to cancer.

Together with collaborators, the Di Croce group uncovered details about the molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs).

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The Lehner lab describes an elegant approach of how to analyze how local and distant genetic variations influence gene expression dynamics.

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The groups of Christoph Müller and Jürg Müller have elucidated the molecular mechanisms for specific DNA binding of PcG complexes.

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This publication from the labs of Aznar-Benitah, Lehner, and Serrano reveals that skin cells activate genes depending on the their internal circadian rhythms.

DPY30 is a key regulator of the proliferation potential of human primary cells that controls proliferation by regulating ID proteins expression, which in turn lead to senescence bypass, as shown in work from the Di Croce team.

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Review by O'Shaughnessy and Hendrich that describes that CHD4 is a defining member of the NuRD complex, but evidence is accumulating that CHD4 also plays important NuRD-independent roles in the DNA-damage response and cell cycle progression, as well as in transcriptional regulation.

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