Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease

In this paper Aloia et al. reveal that ZRF1 plays a crucial role in oncogene-induced senescence (OIS) by activating the INK4/ARF locus, thus working as a tumor suppressor.

This work by Gambetta and Müller has determined that Polycomb repression is the main developmental process requiring Ogt in Drosophila.

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This study shows that the direct interaction between Id1 and Zrf1 blocks Zrf1 recruitment to chromatin thus impairing neural commitment of embryonic stem cells. During differentiation, Id1 levels decrease allowing Zrf1 to activate neural genes.

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The authors analyze the requirement for chromatin factors during normal cell cycle progression and during specific lineage differentiation.

PRC2-associated proteins can help to regulate PCR2 functions in specific and context-dependent manners during development, homeostasis, and disease.

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By elucidating a network of NuRD complex interactions with substoichiometric proteins, the authors have greatly increased our understanding of MBD3–NuRD structure and stability.

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This work demonstrates that the general function of PRC2 in mammals is not to initiate the repression of target genes but rather to recognize their repressed state. thus allowing gene silencing to be maintained.

The authors conclude that UTX overexpression facilitates cellular differentiation of NB4 cells in the presence of physiological concentrations of RA.

By determining the structure of MTA1-RbAp48 structure, the authors were able to reveal that the MTA subunits act as scaffolds for NuRD complex assembly.

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