4DCellFate

Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease

In this article Perez-Lluch et al. show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications.

 

  In this review Mirko Francesconi and Ben Lehner describe some of the computational methods that can be applied to identify and interpret sources of variance in gene expression in whole organisms, organs, tissues or single cells.

 

In this article Pengelly et al. show that H2Aub is essential for viability and required for efficient histone H3 Lys27 trimethylation by PRC2 early in embryogenesis. Furthermore they demonstrate that PRC1 represses canonical target genes independently of H2Aub.

The results of Solip and Lehner reveal how genomic alterations interact cooperatively or partially redundantly to driver cancer changes in different types of cancers.

In this article Baymaz et al. argue that integration of various state-of-the-art technologies, addressing different aspects of transcriptional regulation, is essential to unravel this apparent biological versatility of 'co-repressor' complexes

In this minireview,  Morey, Santanach and Di Croce focus on the latest insights into the molecular mechanisms mediated by the pluripotency factors as well as their roles during differentiation.

Supek and Lehner have determined that DNA mismatch repair is the primary cause of variations in somatic mutation rates.

In this paper Montes et al. report that lncRNA MIR31HG is upregulated in OIS and that knockdown of MIR31HG promotes a strong p16(INK4A)-dependent senescence phenotype.

In this review paper Gambetta and Mueller revisit several of the primary experimental observations that led to current models of how O-GlcNAcylation affects gene expression.

In this paper Palayret et al. demonstrate 3D sectioning with single-molecule super-resolution microscopy by making use of the fitting information that is usually discarded to reject fluorophores that emit from above or below a virtual-'light-sheet'.

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