4DCellFate

Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease

In this article Kloet et al. show that the stoichiometry and genome-wide binding of PRC1 and PRC2 were highly dynamic during neural differentiation. The analyses uncovered dynamic PcG subcomplexes and their widespread colocalization with active chromatin marks during differentiation.

In this paper Julien et al. present a >95% complete local landscape for a defined molecular function—the alternative splicing of a human exon (FAS/CD95 exon 6, involved in the control of apoptosis).

In this paper Pasisni and Di Croce analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.

In this paper Klosin and Lehner review molecular work on inter-generation epigenetic effects in animals and highlight some principles of epigenetic transmission.

In this paper Sebe-Pedros et al. suggest that the appearance of developmental promoters and distal enhancer elements, rather than of gene innovations, may have been the critical events underlying the origin of multicellular organisms.

In this paper Jain and Di Croce discuss, which mutations and deletions of the PRC2 complex have been detected in different cancers, with a specific focus on the overexpression of EZH2 in prostate cancer.

This study of Matthews et al. demonstrates the importance of HDAC3 for the proliferation of leukemia and lymphoma cells, suggesting that HDAC3-selective inhibitors could prove useful for the treatment of hematological malignancies.

This study of Wu et al. links ASXL1-mediated H2A deubiquitylation and transcriptional activation of INK4B expression to its tumor suppressor functions.

Comparative analyses of bacterial, archaeal, fungal, and human cancer genomes have found many links between a gene's biological role and the accrual of synonymous mutations during evolution.

In this paper Morey et al. reveal that Mel18 is required to specify PRC1 function in both a context- and stage-specific manner.

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